五月激情综合美女久久,安徽妇搡BBBB搡BBBB袄爱直播,国产做爰XXXⅩ高潮视频12p,女人野外做爰A片妓女潘金莲,蜜桃又粗又爽成人www网站

Development and validation of machine learning models with?blood-based digital biomarkers for Alzheimer’s disease?diagnosis: a multicohort diagnostic study

Release time: Publisher:MKT Dept Reading times:
【Background】
Alzheimer’s disease (AD) involves complex alterations in biological pathways, making comprehensive blood biomarkers crucial for accurate and earlier diagnosis. However, the cost-effectiveness and operational complexity of method using blood-based biomarkers significantly limit its availability in clinical practice.
【Methods】
We developed low-cost, convenient machine learning-based with digital biomarkers (MLDB) using plasma spectra data to detect AD or mild cognitive impairment (MCI) from healthy controls (HCs) and discriminate AD from different types of neurodegenerative diseases. Retrospective data were gathered for 1324 individuals, including 293 with amyloid beta positive AD, 151 with mild cognitive impairment (MCI), 106 with Lewy body dementia (DLB), 106 with frontotemporal dementia (FTD), 135 with progressive supranuclear palsy (PSP) and 533 healthy controls (HCs) between July 2017 and August 2023.
【Findings】
Random forest classifier and feature selection procedures were used to select digital biomarkers. MLDB achieved area under the curves (AUCs) of 0.92 (AD vs. HC, Sensitivity 88.2%, specificity 84.1%), 0.89 (MCI vs. HC, Sensitivity 88.8%, specificity 86.4%), 0.83 (AD vs. DLB, Sensitivity 77.2%, specificity 74.6%), 0.80 (AD vs. FTD, sensitivity 74.2%, specificity 72.4%), and 0.93 (AD vs. PSP, sensitivity 76.1%, specificity 75.7%). Digital biomarkers distinguishing AD from HC were negatively correlated with plasma p-tau217 (r = ?0.22, p < 0.05) and glial fibrillary acidic protein (GFAP) (r = ?0.09, p < 0.05).
【Interpretation】
The ATR-FTIR (Attenuated Total Reflectance-Fourier Transform Infrared) plasma spectra features can identify AD-related pathological changes. These spectral features serve as digital biomarkers, providing valuable support in the early screening and diagnosis of AD.
【Funding】
The National Natural Science Foundation of China, STI2030-Major Projects, National Key R&D Program of China, Outstanding Youth Fund of Hunan Provincial Natural Science Foundation, Hunan Health Commission Grant, 



DOI:10.1016/j.eclinm.2025.103142

国产成人在线免费观看 | 91色老久久精品偷偷蜜臀 | 国产成人精品女人久久久 | 91精品人妻少妇无码影院 | 特级西西西4444大胆无码 | 久久久久久久久久久国产 | 无码毛多爆乳一二三区 | 人妻无码аⅴ天堂中文在线 | A毛片免费精品一区二区三区 | 红桃视频成人网站免费进 | 亚洲国产精品无码久久小说 | 免费看的黄色视频网站 | 免费看的黄色AAAAA片 | 日本高清视频啊太大了 | 人妻夜夜天天爽麻豆MV | 伊人色干综合在线视频 | 黄色免费视频www | 麻豆mv视频免费播放 | 久久蜜精品国产亚洲AV不卡 | 色欲欧美国产一区二区蜜臀 | 2019天天操天天射天天干 | 水蜜桃AV无码专区亚洲AV麻豆 | 国产一区二区在线视频 | 日韩美女成人性交 | 欧美成人精品A片人妻83 | 亚欧精品久久人人妻人人爽 | av一区二区三区 | A片国产精品黑人粗大 | 爽灬爽灬爽灬毛及A片 | 老司机午夜福利私人定制 | 波多野结衣乳喷高潮五分高潮 | 熟女酒井千波一区二区三区 | 中文字幕乱码人妻无码久久竹菊 | 搡老女人老太婆澡老太婆拍拍免费视频 | 四川少妇精品一级A片 | 在线观看中日无码AV | 国产成人一区二区三区 | 成人四虎成人中文综合 | 国产一级二级三级电影 | 91人妻丰满熟妇a无码 | 国产AV 无码 乱噜噜 |