五月激情综合美女久久,安徽妇搡BBBB搡BBBB袄爱直播,国产做爰XXXⅩ高潮视频12p,女人野外做爰A片妓女潘金莲,蜜桃又粗又爽成人www网站

Tau pathology mediated the plasma biomarkers and cognitive function in patients with mild cognitive impairment

Release time: Publisher:MKT Dept Reading times:

Highlights】:

?Plasma markers (GFAP and NfL) and regional SUVRs of 18F-AV-1451 PET could distinguish patients with MCI from CN in two cohorts.
?Increased tau deposition in the amygdala and left entorhinal cortex and plasma biomarkers were associated with increased plasma biomarkers.
?Tau deposition mediated the plasma biomarkers and cognitive function, indicating the significance of tau pathology in the MCI patients.


Abstract】:

Glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) are putative non-amyloid biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. Hence, this study aimed to demonstrate the relationship between plasma biomarkers (GFAP and NfL) and 18F-AV-1451 tau PET images, and to explore their effects on cognitive function. Ninety-one participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database and 20 participants from the Shanghai Action of Prevention Dementia for the Elderly (SHAPE) cohort underwent plasma biomarker testing, 18F-AV-1451 tau PET scans and cognitive function assessments. Within the ADNI, there were 42 cognitively normal (CN) individuals and 49 with mild cognitive impairment (MCI). Similarly, in the SHAPE, we had 10 CN and 10 MCI participants. We calculated the standardized uptake value ratios (SUVRs) for the regions of interest (ROIs) in the 18F-AV-1451 PET scans. Using plasma biomarkers and regional SUVRs, we trained machine learning models to differentiate between MCI and CN subjects with ADNI database and validated in SHAPE.
Results showed that eight selected variables (including left amygdala SUVR, right amygdala SUVR, left entorhinal cortex SUVR, age, education, plasma NfL, plasma GFAP, plasma GFAP/ NfL) identified by LASSO could differentiate between the MCI and CN individuals, with AUC ranging from 0.783 to 0.926. Additionally, cognitive function was negatively associated with the plasma biomarkers and tau deposition in amygdala and left entorhinal cortex. Increased tau deposition in amygdala and left entorhinal cortex were related to increased plasma biomarkers. Moreover, tau pathology mediated the effect of plasma biomarkers level on the cognitive decline. The present study provides valuable insights into the association among plasma markers (GFAP and NfL), regional tau deposition and cognitive function. This study reports the mediation effect of brain regions tau deposition on the plasma biomarkers level and cognitive fun


DOI https://doi.org/10.1016/j.exger.2024.112535

黄色bb视频在线观看网址 | jiujiuchengren视频 | 欧美精品福利在线观看 | xfplay 无码视频 | 国产又粗又大互换人妻 | 国产黄色视频在线播放 | 国产又粗又黄又爽又硬的蘑菇 | 一日本道电影亚洲色综合 | 有码无码国产在线播放 | 午夜成人免费无码A片 | 很黄很污网站在线观看 | 特级西西人体WWWww | 黄色视频网站在线观看 | 大学生依人在线视频精品 | 亚洲AV无码一区 | 国产高清无码一区二区三区 | 国产亚洲精久久久久久无码老黄瓜 | 无码区免费看一级毛片A片 日本无码 视频在线观音 | 白丝jk糖心视频在线 | 国产寡妇婬乱A毛片91精品 | 亚洲色无码A片一区二区潘甜甜 | 91精品人妻无码系列九色 | X88AV蜜桃臀一区二区 | 蜜桃AV噜噜噜一区二区 | 久久99热这里只频精品 | 国产乱子伦精品无码码专区 | 99久久久国产精品免费蜜臀 | 免费黄色视频下载网站 | silk av在线观看 | 91久久精品无码一区二区天美 | 麻豆精品乱码www久久密的特点 | 另类老妇性BBwBBw | 操b 用力 好舒服 在线观看 | 中文字幕第128页 | 影音先锋亚洲成av人在 | 国精产品一二三探花无码 | 国产精品自拍红桃视频 | 亚洲熟妇AV一区二区三区软件 | 黄色视频网站在线观看直达 | 91人妻人人澡人人爽人 | 国产精品久久久www 18 无套直国产 |